Learning robust representations for physiological time-series signals continues to pose a substantial challenge in developing efficient few-shot learning applications. This difficulty is largely due to the complex pathological variations in biosignals. In this context, this paper introduces a manifold-aware Diffusion-Augmented Contrastive Learning (DACL) framework, which efficiently leverages the generative structure of latent diffusion models with the discriminative power of supervised contrastive learning. The proposed framework operates within a contextualized scattering latent space derived from Scattering Transformer (ST) features. Within a contrastive learning framework, we employ a forward diffusion process in the scattering latent space as a structured manifold-aware feature augmentation technique. We assessed the proposed framework using the PhysioNet 2017 ECG benchmark dataset. The proposed method achieved a competitive AUROC of 0.9741 in the task of detecting atrial fibrillation from a single-lead ECG signal. The proposed framework achieved performance on par with relevant state-of-the-art related works. In-depth evaluation findings suggest that early-stage diffusion serves as an ideal "local manifold explorer," producing embeddings with greater precision than typical augmentation methods while preserving inference efficiency.

In an attempt to address the need for skilled clinicians in heart sound interpretation, recent research efforts on automating cardiac auscultation have explored deep learning approaches. The majority of these approaches have been based on supervised learning that is always challenged in occasions where training data is limited. More recently, there has been a growing interest in potentials of pre-trained self-supervised audio foundation models for biomedical end tasks. Despite exhibiting promising results, these foundational models are typically computationally intensive. Within the context of automatic cardiac auscultation, this study explores a lightweight alternative to these general-purpose audio foundation models by introducing the Scattering Transformer, a novel, training-free transformer architecture for heart murmur detection. The proposed method leverages standard wavelet scattering networks by introducing contextual dependencies in a transformer-like architecture without any backpropagation. We evaluate our approach on the public CirCor DigiScope dataset, directly comparing it against leading general-purpose foundational models. The Scattering Transformer achieves a Weighted Accuracy(WAR) of 0.786 and an Unweighted Average Recall(UAR) of 0.697, demonstrating performance highly competitive with contemporary state of the art methods. This study establishes the Scattering Transformer as a viable and promising alternative in resource-constrained setups.

Patient-independent detection of epileptic activities based on visual spectral representation of continuous EEG (cEEG) has been widely used for diagnosing epilepsy. However, precise detection remains a considerable challenge due to subtle variabilities across subjects, channels and time points. Thus, capturing fine-grained, discriminative features of EEG patterns, which is associated with high-frequency textural information, is yet to be resolved. In this work, we propose Scattering Transformer (ScatterFormer), an invariant scattering transform-based hierarchical Transformer that specifically pays attention to subtle features. In particular, the disentangled frequency-aware attention (FAA) enables the Transformer to capture clinically informative high-frequency components, offering a novel clinical explainability based on visual encoding of multichannel EEG signals. Evaluations on two distinct tasks of epileptiform detection demonstrate the effectiveness our method. Our proposed model achieves median AUCROC and accuracy of 98.14%, 96.39% in patients with Rolandic epilepsy. On a neonatal seizure detection benchmark, it outperforms the state-of-the-art by 9% in terms of average AUCROC.